The Narayan Jagannath Vaidya High School at Karachi was the first government school established in Sindh. It was opened in October 1855 with 68 boys. The original buildings were replaced by the present ones in 1876.
In March 1916, the school had 477 students, of whom 350 were Hindus, 32 Brahmins, 10 Jains, 12 Muslims, 66 Parsis and seven Indian Jews.
Notable alumni include Jamshed Nusserwanjee Mehta, who was elected a councilor of Karachi in 1918, and the president of the Council in 1922. He became the first mayor of Karachi in 1933 when the Karachi Municipal Corporation was formed.